60S acidic ribosomal protein P0

RPLP0
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V6X, 5AJ0, 3J92, 4V5Z,%%s4V5Z, 5AJ0, 4V6X, 3J92
Identifiers
Aliases	RPLP0, L10E, LP0, P0, PRLP0, RPP0, ribosomal protein lateral stalk subunit P0
External IDs	OMIM: 180510; MGI: 1927636; HomoloGene: 6517; GeneCards: RPLP0; OMA:RPLP0 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,201,235 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,701,786 bp
RNA expression pattern
	Top expressed in
	gonad; ; stromal cell of endometrium; ; ventricular zone; ; mucosa of esophagus; ; skin of leg; ; islet of Langerhans; ; ganglionic eminence; ; right uterine tube; ; skin of abdomen; ; right ovary;
	Top expressed in
	epiblast; ; ventricular zone; ; embryo; ; lip; ; embryo; ; ganglionic eminence; ; zone of skin; ; esophagus; ; urinary bladder; ; lens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; structural constituent of ribosome; RNA binding; large ribosomal subunit rRNA binding; peptide binding;
Cellular component	ribosome; focal adhesion; intracellular anatomical structure; cytoplasmic ribonucleoprotein granule; cytosolic large ribosomal subunit; extracellular exosome; cytoplasm; nucleus; endoplasmic reticulum; cytosol; membrane; postsynaptic density; postsynapse; ribonucleoprotein complex; dendrite; synapse;
Biological process	ribosome biogenesis; viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein biosynthesis; rRNA processing; viral process; interleukin-12-mediated signaling pathway; ribosomal large subunit assembly; cytoplasmic translation; lactation; response to selenium ion; cellular response to cAMP; cellular response to interleukin-4; cellular response to Thyroid stimulating hormone; cellular response to phorbol 13-acetate 12-myristate;
	Sources:Amigo / QuickGO
Orthologs
	6175
	11837
	ENSG00000089157
	ENSMUSG00000067274
	P05388
	P14869
	NM_053275; NM_001002
	NM_007475
	NP_000993; NP_444505; NP_000993.1; NP_444505.1
	NP_031501
	Wikidata
View/Edit Human	View/Edit Mouse

60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.

Ribosomes catalyze protein synthesis and consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.