40S ribosomal protein S5

RPS5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 4V5Z, 5FLX, 4D61, 4UJC,%%s4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5A2Q, 4V6X, 4UJD, 3J7P, 5AJ0, 4KZZ, 4UG0, 4UJE, 4UJC, 5FLX
Identifiers
Aliases	RPS5, S5, ribosomal protein S5
External IDs	OMIM: 603630; MGI: 1097682; HomoloGene: 783; GeneCards: RPS5; OMA:RPS5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	58,394,806 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	12,660,613 bp
RNA expression pattern
	Top expressed in
	gonad; ; vulva; ; trabecular bone; ; mucosa of sigmoid colon; ; skin of arm; ; human penis; ; left ovary; ; oral cavity; ; superficial temporal artery; ; skin of thigh;
	Top expressed in
	Gonadal ridge; ; mandibular prominence; ; maxillary prominence; ; efferent ductule; ; internal carotid artery; ; somite; ; medial ganglionic eminence; ; precursor cell; ; migratory enteric neural crest cell; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; mRNA binding; RNA binding; rRNA binding;
Cellular component	cytosol; ribosome; membrane; focal adhesion; small ribosomal subunit; extracellular exosome; extracellular matrix; nucleoplasm; cytosolic small ribosomal subunit; ribonucleoprotein complex;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; regulation of translational fidelity; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing; protein biosynthesis; ribosomal small subunit assembly;
	Sources:Amigo / QuickGO
Orthologs
	6193
	20103
	ENSG00000083845
	ENSMUSG00000012848
	P46782
	P97461
	NM_001009
	NM_009095
	NP_001000; NP_001000.2
	NP_033121
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.

Ribosomes, the organelles that catalyze protein synthesis, in eukaryotes, consist of a small 40S subunit and a large 60S subunit (whereas prokaryotic ribosomes are 70 Svedberg units, composed of 50S and 30S subunits). They are located in the cytoplasm. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the eukaryotic 40S subunit. The protein belongs to the S7P family of ribosomal proteins. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.