RPS6KA5

RPS6KA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VZO, 3KN5, 3KN6
Identifiers
Aliases	RPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
External IDs	OMIM: 603607; MGI: 1920336; HomoloGene: 48302; GeneCards: RPS6KA5; OMA:RPS6KA5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	91,060,641 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	100,693,242 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tail of epididymis; ; nipple; ; corpus callosum; ; inferior ganglion of vagus nerve; ; buccal mucosa cell; ; Brodmann area 23; ; Pons; ; bronchial epithelial cell; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	dorsal striatum; ; zygote; ; olfactory tubercle; ; secondary oocyte; ; lobe of cerebellum; ; cerebellar vermis; ; nucleus accumbens; ; gastrula; ; subiculum; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein binding; ATP binding; magnesium ion binding; protein serine/threonine kinase activity;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	intracellular signal transduction; regulation of transcription, DNA-templated; epidermal growth factor receptor signaling pathway; phosphorylation; stimulatory C-type lectin receptor signaling pathway; axon guidance; positive regulation of histone acetylation; interleukin-1-mediated signaling pathway; protein phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; inflammatory response; negative regulation of transcription, DNA-templated; negative regulation of cytokine production; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9252
	73086
	ENSG00000100784
	ENSMUSG00000021180
	O75582
	Q8C050
NM_004755; NM_182398; NM_001322227; NM_001322228; NM_001322229;
	NM_001322230; NM_001322231; NM_001322232; NM_001322233; NM_001322234; NM_001322235; NM_001322236; NM_001322237; NM_001322238
	NM_153587; NM_001330702
NP_001309156; NP_001309157; NP_001309158; NP_001309159; NP_001309160;
	NP_001309161; NP_001309162; NP_001309163; NP_001309164; NP_001309165; NP_001309166; NP_001309167; NP_004746; NP_872198
	NP_001317631; NP_705815
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.