P70-S6 Kinase 1

RPS6KB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A60, 3A61, 3A62, 3WE4, 3WF5, 3WF6, 3WF7, 3WF8, 3WF9, 4L3J, 4L3L, 4L42, 4L43, 4L44, 4L45, 4L46, 4RLO, 4RLP
Identifiers
Aliases	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha, P70-S6 Kinase 1, ribosomal protein S6 kinase B1, p70S6K, p70S6 kinase
External IDs	OMIM: 608938; MGI: 1270849; HomoloGene: 81703; GeneCards: RPS6KB1; OMA:RPS6KB1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	59,950,574 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	86,544,805 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; Achilles tendon; ; middle temporal gyrus; ; tibia; ; epithelium of colon; ; gingival epithelium; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	lacrimal gland; ; tail of embryo; ; Paneth cell; ; genital tubercle; ; renal corpuscle; ; ureter; ; condyle; ; fossa; ; substantia nigra; ; migratory enteric neural crest cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; peptide binding; protein binding; identical protein binding; protein serine/threonine/tyrosine kinase activity; ATP binding; kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity; PDZ domain binding; protein phosphatase 2A binding;
Cellular component	cytoplasm; cytosol; membrane; synapse; nucleoplasm; cell surface; mitochondrial outer membrane; cell junction; mitochondrion; perinuclear region of cytoplasm; neuron projection; nucleus;
Biological process	germ cell development; response to amino acid; response to glucagon; response to organic cyclic compound; protein kinase B signaling; response to nutrient; phosphorylation; regulation of glucose import; response to testosterone; negative regulation of extrinsic apoptotic signaling pathway; cellular response to growth factor stimulus; skeletal muscle contraction; response to mechanical stimulus; ageing; response to leucine; cellular response to organic cyclic compound; positive regulation of mitotic cell cycle; negative regulation of apoptotic process; response to heat; response to glucocorticoid; response to glucose; response to peptide hormone; behavioral fear response; positive regulation of translation; response to organic substance; positive regulation of smooth muscle cell migration; response to tumor necrosis factor; response to insulin; response to lipopolysaccharide; negative regulation of insulin receptor signaling pathway; cellular response to hormone stimulus; long-term memory; response to wounding; response to organonitrogen compound; response to electrical stimulus involved in regulation of muscle adaptation; skeletal muscle atrophy; cell cycle; response to ethanol; positive regulation of translational initiation; cell migration; response to toxic substance; positive regulation of skeletal muscle tissue growth; regulation of translation; phosphatidylinositol-mediated signaling; signal transduction; positive regulation of smooth muscle cell proliferation; apoptotic process; protein phosphorylation; cellular response to dexamethasone stimulus; cellular response to insulin stimulus; G1/S transition of mitotic cell cycle; peptidyl-serine phosphorylation; TOR signaling; cellular response to interferon-gamma; long-chain fatty acid import into cell; intracellular signal transduction; response to nutrient levels;
	Sources:Amigo / QuickGO
Orthologs
	6198
	72508
	ENSG00000108443
	ENSMUSG00000020516
	P23443
	Q8BSK8
	NM_001272042; NM_001272043; NM_001272044; NM_001272060; NM_003161
	NM_001114334; NM_028259; NM_001363162
NP_001258971; NP_001258972; NP_001258973; NP_001258989; NP_003152;
	NP_001356598; NP_001356599; NP_001356600; NP_001356601; NP_001356602; NP_001356603; NP_001356604; NP_001356605; NP_001356606; NP_001356607; NP_001356608
	NP_001107806; NP_082535; NP_001350091
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. As the name suggests, its target substrate is the S6 ribosomal protein. Phosphorylation of S6 induces protein synthesis at the ribosome.

The phosphorylation of p70S6K at threonine 389 has been used as a hallmark of activation by mTOR and correlated with autophagy inhibition in various situations. However, several recent studies suggest that the activity of p70S6K plays a more positive role in the increase of autophagy.