RPS6KB2

RPS6KB2
Identifiers
Aliases	RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb, ribosomal protein S6 kinase B2, S6KB, S6KI(2), S6Kbeta
External IDs	OMIM: 608939; MGI: 1927343; HomoloGene: 68374; GeneCards: RPS6KB2; OMA:RPS6KB2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,435,401 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; granulocyte; ; body of stomach; ; apex of heart; ; right lobe of liver; ; right hemisphere of cerebellum; ; anterior pituitary; ; muscle of thigh; ; mucosa of transverse colon;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; peptide binding; kinase activity; protein serine/threonine kinase activity; ATP binding; ribosomal protein S6 kinase activity;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	intracellular signal transduction; protein biosynthesis; phosphorylation; protein phosphorylation; positive regulation of translational initiation; signal transduction; protein kinase B signaling; TOR signaling;
	Sources:Amigo / QuickGO
Orthologs
	6199
	58988
	ENSG00000175634
	ENSMUSG00000024830
	Q9UBS0
	Q9Z1M4
	NM_001007071; NM_003952
	NM_021485
	NP_003943
	NP_067460.1
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.