RSU1

RSU1
Identifiers
Aliases	RSU1, RSP-1, Ras suppressor protein 1
External IDs	OMIM: 179555; MGI: 103040; HomoloGene: 7521; GeneCards: RSU1; OMA:RSU1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	16,817,463 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,276,226 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; left coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; Achilles tendon; ; monocyte; ; saphenous vein; ; stromal cell of endometrium;
	Top expressed in
	genital tubercle; ; granulocyte; ; ascending aorta; ; umbilical cord; ; calvaria; ; external carotid artery; ; tail of embryo; ; endothelial cell of lymphatic vessel; ; left lung lobe; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; extracellular exosome; focal adhesion;
Biological process	positive regulation of GTPase activity; regulation of cell-substrate adhesion; signal transduction; positive regulation of cell-substrate adhesion;
	Sources:Amigo / QuickGO
Orthologs
	6251
	20163
	ENSG00000148484
	ENSMUSG00000026727
	Q15404
	Q01730
	NM_012425; NM_152724
	NM_009105
	NP_036557; NP_689937
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.