RUFY2

RUFY2
Identifiers
Aliases	RUFY2, RABIP4R, ZFYVE13, RUN and FYVE domain containing 2
External IDs	OMIM: 610328; MGI: 1917682; HomoloGene: 23064; GeneCards: RUFY2; OMA:RUFY2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	68,407,294 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,852,989 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; right hemisphere of cerebellum; ; C1 segment; ; tendon of biceps brachii; ; sural nerve; ; Brodmann area 9; ; right frontal lobe; ; ganglionic eminence; ; prefrontal cortex; ; epithelium of colon;
	Top expressed in
	Rostral migratory stream; ; lumbar spinal ganglion; ; tail of embryo; ; superior frontal gyrus; ; neural layer of retina; ; primary visual cortex; ; cerebellar cortex; ; genital tubercle; ; olfactory epithelium; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; SH3 domain binding;
Cellular component	nucleus; cytoplasm; endosome;
Biological process	regulation of endocytosis; biological process;
	Sources:Amigo / QuickGO
Orthologs
	55680
	70432
	ENSG00000204130
	ENSMUSG00000020070
	Q8WXA3
	Q8R4C2
	NM_001042417; NM_001278225; NM_017987; NM_001330103
	NM_027425
	NP_001035882; NP_001265154; NP_001317032; NP_060457
	NP_081701
	Wikidata
View/Edit Human	View/Edit Mouse

RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the RUFY2 gene. The RUFY2 gene is named for two of its domains, the RUN domain and FYVE domains. RUFY2 is a member of the RUFY family of proteins that include RUFY1, RUFY2, RUFY3, and RUFY4. RUFY2 protein has a dynamic role in endosomal membrane trafficking.