RUNX3

RUNX3
Identifiers
Aliases	RUNX3, AML2, CBFA3, PEBP2aC, runt related transcription factor 3, RUNX family transcription factor 3
External IDs	OMIM: 600210; MGI: 102672; HomoloGene: 37914; GeneCards: RUNX3; OMA:RUNX3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,965,121 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,905,301 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; buccal mucosa cell; ; lymph node; ; blood; ; appendix; ; mononuclear cell; ; tibia; ; spleen; ; monocyte; ; bone marrow cells;
	Top expressed in
	membranous bone; ; Dermatocranium; ; mandible; ; spleen; ; mesenteric lymph nodes; ; clavicle; ; blood; ; tongue; ; urethra; ; maxilla;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; protein binding; ATP binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleolus; intracellular membrane-bounded organelle; nucleoplasm; cytosol; core-binding factor complex;
Biological process	peripheral nervous system neuron development; regulation of transcription, DNA-templated; chondrocyte differentiation; ossification; regulation of transcription by RNA polymerase II; negative regulation of cell cycle; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; protein phosphorylation; negative regulation of epithelial cell proliferation; regulation of cell differentiation; response to transforming growth factor beta; hemopoiesis; negative regulation of CD4-positive, alpha-beta T cell differentiation; positive regulation of CD8-positive, alpha-beta T cell differentiation; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	864
	12399
	ENSG00000020633
	ENSMUSG00000070691
	Q13761
	Q3U1Q3
	NM_001031680; NM_004350; NM_001320672
	NM_019732; NM_001369050
	NP_001026850; NP_001307601; NP_004341
	NP_062706; NP_001355979
	Wikidata
View/Edit Human	View/Edit Mouse

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.