Relaxin/insulin-like family peptide receptor 1

RXFP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JM4, 2M7P
Identifiers
Aliases	RXFP1, LGR7, RXFPR1, Relaxin/insulin-like family peptide receptor 1, relaxin/insulin like family peptide receptor 1, relaxin family peptide receptor 1
External IDs	OMIM: 606654; MGI: 2682211; HomoloGene: 11007; GeneCards: RXFP1; OMA:RXFP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	158,653,372 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	79,645,187 bp
RNA expression pattern
	Top expressed in
	decidua; ; endothelial cell; ; endometrium; ; Brodmann area 46; ; testicle; ; prefrontal cortex; ; Brodmann area 9; ; superior frontal gyrus; ; Brodmann area 23; ; cingulate gyrus;
	Top expressed in
	uterus; ; genital tubercle; ; primary visual cortex; ; superior frontal gyrus; ; cervix; ; dentate gyrus of hippocampal formation granule cell; ; atrioventricular valve; ; muscle of thigh; ; hippocampus proper; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity; metal ion binding; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	signal transduction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; hormone-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	59350
	381489
	ENSG00000171509
	ENSMUSG00000034009
	Q9HBX9
	Q6R6I7
NM_001253727; NM_001253728; NM_001253729; NM_001253730; NM_001253732;
	NM_001253733; NM_021634; NM_001363776
	NM_212452
NP_001240656; NP_001240657; NP_001240658; NP_001240659; NP_001240661;
	NP_001240662; NP_067647; NP_001350705
	NP_997617
	Wikidata
View/Edit Human	View/Edit Mouse

Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors. It is a rhodopsin-like GPCR which is unusual in this class as it contains a large extracellular binding and signalling domain. Some reports suggest that RXFP1 forms homodimers, however the most recent evidence indicates that relaxin binds a non-homodimer of RXFP1.