Related to receptor tyrosine kinase

RYK
Identifiers
Aliases	RYK, D3S3195, JTK5, JTK5A, RYK1, receptor-like tyrosine kinase, receptor like tyrosine kinase
External IDs	OMIM: 600524; MGI: 101766; HomoloGene: 68287; GeneCards: RYK; OMA:RYK - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	134,250,859 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	102,785,504 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; left ovary; ; saphenous vein; ; gastric mucosa; ; urethra; ; ventricular zone; ; germinal epithelium; ; right ovary; ; stromal cell of endometrium;
	Top expressed in
	tail of embryo; ; secondary oocyte; ; genital tubercle; ; ventricular zone; ; zygote; ; lip; ; muscle of thigh; ; epiblast; ; calvaria; ; molar;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein tyrosine kinase activity; transferase activity; transmembrane signaling receptor activity; kinase activity; Wnt-activated receptor activity; ATP binding; protein binding; frizzled binding; Wnt-protein binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; receptor tyrosine kinase; transmembrane receptor protein tyrosine kinase activity; protein kinase activity;
Cellular component	cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; nucleus; receptor complex;
Biological process	positive regulation of MAPK cascade; corpus callosum development; signal transduction; canonical Wnt signaling pathway; non-canonical Wnt signaling pathway; neurogenesis; commissural neuron axon guidance; neuron projection development; protein phosphorylation; synapse assembly; chemorepulsion of dopaminergic neuron axon; neuron differentiation; cell proliferation in midbrain; phosphorylation; axonogenesis; axon guidance; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; midbrain dopaminergic neuron differentiation; planar cell polarity pathway involved in axon guidance; Wnt signaling pathway; peptidyl-tyrosine phosphorylation; skeletal system morphogenesis; negative regulation of axon extension involved in axon guidance; negative chemotaxis; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	6259
	20187
	ENSG00000163785
	ENSMUSG00000032547
	P34925
	Q01887
	NM_001005861; NM_002958
	NM_001042607; NM_013649; NM_001284258
	NP_001005861; NP_002949
	NP_001036072; NP_001271187; NP_038677
	Wikidata
View/Edit Human	View/Edit Mouse

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.