Ryanodine receptor 2

RYR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JKQ
Identifiers
Aliases	RYR2, ARVC2, ARVD2, RYR-2, RyR, VTSIP, ryanodine receptor 2, VACRDS
External IDs	OMIM: 180902; MGI: 99685; HomoloGene: 37423; GeneCards: RYR2; OMA:RYR2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	237,833,988 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	12,106,945 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; apex of heart; ; right auricle of heart; ; endothelial cell; ; Brodmann area 23; ; vena cava; ; primary visual cortex; ; right hemisphere of cerebellum;
	Top expressed in
	myocardium of ventricle; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; interventricular septum; ; atrium; ; atrioventricular valve; ; lateral septal nucleus; ; dentate gyrus; ; primary motor cortex; ; anterior amygdaloid area;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter binding; calcium channel activity; calcium-induced calcium release activity; protein kinase A catalytic subunit binding; organic cyclic compound binding; protein self-association; ion channel activity; protein binding; identical protein binding; enzyme binding; suramin binding; protein kinase A regulatory subunit binding; protein kinase binding; calcium-release channel activity; ryanodine-sensitive calcium-release channel activity; calcium ion binding; calmodulin binding;
Cellular component	integral component of membrane; calcium channel complex; membrane; sarcomere; junctional sarcoplasmic reticulum membrane; sarcoplasmic reticulum; Z discdkac; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; plasma membrane; protein-containing complex; cytoplasmic vesicle membrane; sarcolemma;
Biological process	response to muscle stretch; release of sequestered calcium ion into cytosol; calcium ion transport into cytosol; regulation of cardiac conduction; regulation of cardiac muscle contraction by calcium ion signaling; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to hypoxia; cardiac muscle contraction; regulation of cytosolic calcium ion concentration; positive regulation of the force of heart contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; cardiac muscle hypertrophy; ventricular cardiac muscle cell action potential; cell communication by electrical coupling involved in cardiac conduction; cellular calcium ion homeostasis; establishment of protein localization to endoplasmic reticulum; ion transport; BMP signaling pathway; left ventricular cardiac muscle tissue morphogenesis; regulation of heart rate; positive regulation of heart rate; detection of calcium ion; response to redox state; cellular response to epinephrine stimulus; multicellular organism development; ion transmembrane transport; positive regulation of sequestering of calcium ion; embryonic heart tube morphogenesis; calcium ion transmembrane transport; cellular response to caffeine; sarcoplasmic reticulum calcium ion transport; canonical Wnt signaling pathway; regulation of SA node cell action potential; response to caffeine; regulation of cardiac muscle contraction; regulation of ventricular cardiac muscle cell action potential; regulation of AV node cell action potential; calcium-mediated signaling using intracellular calcium source; response to muscle activity; calcium ion transport; calcium-mediated signaling; type B pancreatic cell apoptotic process; regulation of atrial cardiac muscle cell action potential; positive regulation of ATPase-coupled calcium transmembrane transporter activity; Purkinje myocyte to ventricular cardiac muscle cell signaling; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6262
	20191
	ENSG00000198626
	ENSMUSG00000021313
	Q92736
	E9Q401
	NM_001035
	NM_023868
	NP_001026
	NP_076357
	Wikidata
View/Edit Human	View/Edit Mouse

Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions.