Ryanodine receptor 3

RYR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ERV
Identifiers
Aliases	RYR3, RYR-3, ryanodine receptor 3
External IDs	OMIM: 180903; MGI: 99684; HomoloGene: 68151; GeneCards: RYR3; OMA:RYR3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	33,866,121 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	113,047,441 bp
RNA expression pattern
	Top expressed in
	thoracic diaphragm; ; sural nerve; ; right hemisphere of cerebellum; ; caudate nucleus; ; putamen; ; right uterine tube; ; nucleus accumbens; ; right frontal lobe; ; body of uterus; ; gastrocnemius muscle;
	Top expressed in
	olfactory tubercle; ; lateral septal nucleus; ; medial dorsal nucleus; ; subiculum; ; mammillary body; ; nucleus accumbens; ; motor neuron; ; lateral geniculate nucleus; ; globus pallidus; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	ryanodine-sensitive calcium-release channel activity; calcium channel activity; calcium-release channel activity; calmodulin binding; ion channel activity; calcium-induced calcium release activity; calcium ion binding;
Cellular component	organelle membrane; integral component of membrane; membrane; intracellular membrane-bounded organelle; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane; smooth endoplasmic reticulum; Z discdkac; cytoplasmic vesicle membrane; calcium channel complex; sarcolemma;
Biological process	cellular response to calcium ion; cellular response to magnesium ion; regulation of cardiac conduction; cellular calcium ion homeostasis; ion transport; ion transmembrane transport; calcium ion transmembrane transport; cellular response to caffeine; cellular response to ATP; protein homotetramerization; calcium ion transport; negative regulation of cytosolic calcium ion concentration; transmembrane transport; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	6263
	20192
	ENSG00000198838
	ENSMUSG00000057378
	Q15413
	A2AGL3
	NM_001036; NM_001243996
	NM_177652; NM_001319156
	NP_001027; NP_001230925
	NP_001306085
	Wikidata
View/Edit Human	View/Edit Mouse

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.