RAC1

RAC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0
Identifiers
Aliases	RAC1, MIG5, Rac-1, TC-25, p21-Rac1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), Rac family small GTPase 1, MRD48
External IDs	OMIM: 602048; MGI: 97845; HomoloGene: 69035; GeneCards: RAC1; OMA:RAC1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	6,403,967 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	143,513,791 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; middle temporal gyrus; ; postcentral gyrus; ; palpebral conjunctiva; ; gingival epithelium; ; parietal pleura; ; Brodmann area 23; ; entorhinal cortex; ; Brodmann area 46; ; Region I of hippocampus proper;
	Top expressed in
	entorhinal cortex; ; left lung; ; perirhinal cortex; ; tail of embryo; ; CA3 field; ; triceps brachii muscle; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; left lung lobe; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone deacetylase binding; Rho GDP-dissociation inhibitor binding; GTP-dependent protein binding; GTPase activity; enzyme binding; protein binding; thioesterase binding; protein kinase binding; nucleotide binding; GTP binding; protein serine/threonine kinase activity; protein-containing complex binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; ATPase binding;
Cellular component	cytoplasm; cytosol; membrane; focal adhesion; melanosome; ruffle membrane; trans-Golgi network; nucleus; cell projection; extrinsic component of plasma membrane; extracellular exosome; lamellipodium; early endosome membrane; plasma membrane; actin filament; cytoplasmic ribonucleoprotein granule; endoplasmic reticulum membrane; Golgi membrane; phagocytic cup; cytoplasmic vesicle; extracellular matrix; secretory granule membrane; dendritic spine; recycling endosome membrane; postsynapse; glutamatergic synapse; ficolin-1-rich granule membrane;
Biological process	positive regulation of Rho protein signal transduction; regulation of respiratory burst; non-canonical Wnt signaling pathway; positive regulation of protein phosphorylation; positive regulation of actin filament polymerization; regulation of neuron maturation; negative regulation of receptor-mediated endocytosis; platelet activation; Fc-epsilon receptor signaling pathway; cellular response to mechanical stimulus; phagocytosis, engulfment; vascular endothelial growth factor receptor signaling pathway; substrate adhesion-dependent cell spreading; cell population proliferation; ruffle assembly; lamellipodium assembly; dopaminergic neuron differentiation; cell-cell junction organization; Fc-gamma receptor signaling pathway involved in phagocytosis; ruffle organization; actin filament organization; cell motility; anatomical structure morphogenesis; bone resorption; response to wounding; protein localization to plasma membrane; inflammatory response; regulation of small GTPase mediated signal transduction; positive regulation of cell-substrate adhesion; G protein-coupled receptor signaling pathway; neuron projection morphogenesis; epithelial cell morphogenesis; dendrite morphogenesis; regulation of hydrogen peroxide metabolic process; engulfment of apoptotic cell; dendrite development; auditory receptor cell morphogenesis; hyperosmotic response; cerebral cortex GABAergic interneuron development; chemotaxis; positive regulation of DNA replication; actin filament polymerization; cell adhesion; negative regulation of interleukin-23 production; homeostasis of number of cells within a tissue; cell-matrix adhesion; localization within membrane; actin cytoskeleton organization; regulation of cell size; anatomical structure arrangement; intracellular signal transduction; regulation of cell migration; endocytosis; ephrin receptor signaling pathway; T cell costimulation; blood coagulation; mitigation of host defenses by virus; synaptic transmission, GABAergic; mast cell chemotaxis; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of substrate adhesion-dependent cell spreading; embryonic olfactory bulb interneuron precursor migration; cytoskeleton organization; cochlea morphogenesis; positive regulation of neutrophil chemotaxis; positive regulation of apoptotic process; regulation of cell morphogenesis; positive regulation of focal adhesion assembly; regulation of fibroblast migration; positive regulation of lamellipodium assembly; cerebral cortex radially oriented cell migration; cell migration; semaphorin-plexin signaling pathway; positive regulation of stress fiber assembly; axon guidance; small GTPase mediated signal transduction; positive regulation of GTPase activity; Wnt signaling pathway, planar cell polarity pathway; midbrain dopaminergic neuron differentiation; neuron migration; protein phosphorylation; Rho protein signal transduction; regulation of lamellipodium assembly; Rac protein signal transduction; cell projection assembly; positive regulation of microtubule polymerization; neutrophil degranulation; regulation of nitric oxide biosynthetic process; phosphatidylinositol phosphate biosynthetic process; hepatocyte growth factor receptor signaling pathway; regulation of stress fiber assembly; positive regulation of protein kinase B signaling; motor neuron axon guidance; regulation of neutrophil migration; positive regulation of insulin secretion involved in cellular response to glucose stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5879
	19353
	ENSG00000136238
	ENSMUSG00000001847
	P63000
	P63001
	NM_198829; NM_006908; NM_018890
	NM_009007; NM_001347530
	NP_008839; NP_061485
	NP_001334459; NP_033033
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related C3 botulinum toxin substrate 1, is a protein that in humans is encoded by the RAC1 gene. This gene can produce a variety of alternatively spliced versions of the Rac1 protein, which appear to carry out different functions.