Ramatroban

Ramatroban
Clinical data
Trade names	Baynas
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral (tablets)
ATC code	None;
Legal status
Legal status	Rx-only (JP);
Identifiers
	IUPAC name 3-((3R)-3-{[(4-fluorophenyl)sulfonyl]amino}-1,2,3,4-tetrahydro-9H-carbazol-9-yl)propanoic acid;
CAS Number	116649-85-5;
PubChem CID	123879;
IUPHAR/BPS	1910;
ChemSpider	110413;
UNII	P1ALI72U6C;
KEGG	D01128;
ChEMBL	ChEMBL361812;
CompTox Dashboard (EPA)	DTXSID1046685 ;
ECHA InfoCard	100.159.668
Chemical and physical data
Formula	C21H21FN2O4S
Molar mass	416.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC2=C(CC1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O;
	InChI InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1; Key:LDXDSHIEDAPSSA-OAHLLOKOSA-N;

Ramatroban (INN; also known as BAY u3405) is a thromboxane receptor antagonist. It is also a DP₂ receptor antagonist.

Ramatroban is indicated for the treatment of coronary artery disease. It has also been used for the treatment of asthma.

It has been suggested that ramatroban, by modulating DP₂ receptor, can reverse viremia-associated proinflammatory and prothrombotic processes which are similar to those induced by SARS-Cov-2. Hence, ramatroban, that has been used for the treatment of allergic rhinitis in Japan for the past two decades with a well established safety profile, merits investigation as a novel immunotherapy for the treatment of COVID-19 disease, although no clinical trial has yet been conducted.

Ramatroban was developed by the German pharmaceutical company Bayer AG and is co-marketed in Japan by Bayer Yakuhin then marketed by Kyorin Pharmaceutical and Nippon Shinyaku Co., Ltd. under the trade name Baynas.