Unoprostone

Unoprostone
Clinical data
Trade names	Rescula
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical (eye drops)
ATC code	S01EE02 (WHO) ;
Legal status
Legal status	US: Discontinued;
Pharmacokinetic data
Elimination half-life	14 min
Excretion	Renal
Identifiers
	IUPAC name (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl); cyclopentyl]hept-5-enoic acid;
CAS Number	120373-36-6 120373-24-2 (isopropyl ester);
PubChem CID	5311236;
DrugBank	DB06826 ;
ChemSpider	4470755 ;
UNII	6X4F561V3W;
KEGG	D08661 ;
ChEMBL	ChEMBL1201407 ;
CompTox Dashboard (EPA)	DTXSID80905120 ;
ECHA InfoCard	100.227.145
Chemical and physical data
Formula	C22H38O5
Molar mass	382.541 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(=O)CCCCCCC;
	InChI InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1 ; Key:TVHAZVBUYQMHBC-SNHXEXRGSA-N ;
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Unoprostone (INN) is a prostaglandin analogue. Its isopropyl ester, unoprostone isopropyl, was marketed under the trade name Rescula for the management of open-angle glaucoma and ocular hypertension.

It was approved by the Food and Drug Administration in 2000.

In 2009, Sucampo Pharmaceuticals acquired the rights to the drug in the U.S. and Canada.

In 2015, the drug was discontinued in the U.S.