Retinoic acid receptor alpha

RARA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13
Identifiers
Aliases	RARA, NR1B1, RAR, retinoic acid receptor alpha, RARalpha
External IDs	OMIM: 180240; MGI: 97856; HomoloGene: 20262; GeneCards: RARA; OMA:RARA - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,357,643 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,865,768 bp
RNA expression pattern
	Top expressed in
	lactiferous duct; ; monocyte; ; granulocyte; ; blood; ; gallbladder; ; right lung; ; left uterine tube; ; upper lobe of left lung; ; tibial arteries; ; canal of the cervix;
	Top expressed in
	granulocyte; ; genital tubercle; ; tail of embryo; ; lip; ; yolk sac; ; spermatocyte; ; neural layer of retina; ; spermatid; ; molar; ; female urethra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	retinoic acid binding; transcription corepressor activity; protein domain specific binding; DNA-binding transcription factor activity; nuclear receptor activity; mRNA 5'-UTR binding; signaling receptor binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; retinoic acid-responsive element binding; transcription factor binding; metal ion binding; steroid hormone receptor activity; enzyme binding; zinc ion binding; protein binding; DNA binding; sequence-specific DNA binding; transcription coactivator activity; protein kinase A binding; protein kinase B binding; translation repressor activity, mRNA regulatory element binding; alpha-actinin binding; protein heterodimerization activity; chromatin DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; transcription cis-regulatory region binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	cytoplasm; actin cytoskeleton; perinuclear region of cytoplasm; neuron projection; nucleus; cell surface; nucleoplasm; soma; dendrite; cytosol; RNA polymerase II transcription regulator complex;
Biological process	growth plate cartilage development; germ cell development; cellular response to retinoic acid; ureteric bud development; positive regulation of interleukin-5 production; prostate gland development; limb development; apoptotic cell clearance; chondroblast differentiation; regulation of granulocyte differentiation; protein phosphorylation; response to vitamin A; face development; spermatogenesis; response to ethanol; negative regulation of cell population proliferation; steroid hormone mediated signaling pathway; regulation of apoptotic process; response to cytokine; negative regulation of translation; regulation of transcription, DNA-templated; negative regulation of cell differentiation; negative regulation of gene expression; transcription, DNA-templated; cellular response to estrogen stimulus; positive regulation of transcription, DNA-templated; positive regulation of cell cycle; regulation of myelination; positive regulation of neuron differentiation; negative regulation of tumor necrosis factor production; transcription initiation from RNA polymerase II promoter; trachea cartilage development; glandular epithelial cell development; male gonad development; negative regulation of cartilage development; response to retinoic acid; negative regulation of granulocyte differentiation; multicellular organism growth; female pregnancy; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of interleukin-4 production; regulation of synaptic plasticity; outflow tract septum morphogenesis; negative regulation of transcription, DNA-templated; negative regulation of interferon-gamma production; response to estradiol; negative regulation of translational initiation; embryonic camera-type eye development; positive regulation of interleukin-13 production; neural tube closure; positive regulation of binding; retinoic acid receptor signaling pathway; positive regulation of gene expression; Sertoli cell fate commitment; positive regulation of cell population proliferation; positive regulation of T-helper 2 cell differentiation; ventricular cardiac muscle cell differentiation; liver development; cellular response to lipopolysaccharide; bone development; hippocampus development; signal transduction; positive regulation of transcription by RNA polymerase II; multicellular organism development; hormone-mediated signaling pathway; cell differentiation; response to lipid; gland development; bone morphogenesis; epithelium development;
	Sources:Amigo / QuickGO
Orthologs
	5914
	19401
	ENSG00000131759
	ENSMUSG00000037992
	P10276; Q6I9R7
	P11416
	NM_000964; NM_001024809; NM_001033603; NM_001145301; NM_001145302
	NM_001176528; NM_001177302; NM_001177303; NM_009024; NM_001361954
NP_000955; NP_001019980; NP_001138773; NP_001138774; NP_000955.1;
	NP_001138773.1
	NP_001169999; NP_001170773; NP_001170774; NP_033050; NP_001348883
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1), is a nuclear receptor that in humans is encoded by the RARA gene.

NR1B1 is a gene with a protein product and has a chromosomal location of 17q21.2. RARA codes for the nuclear hormone receptor retinoic acid receptor, alpha subtype, a transcription factor. There are another two subtypes of RARs: beta and gamma subtypes.