Rev-ErbA alpha

NR1D1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A6Y, 1GA5, 1HLZ, 3N00
Identifiers
Aliases	NR1D1, EAR1, THRA1, THRAL, ear-1, hRev, nuclear receptor subfamily 1 group D member 1, REVERBA, REVERBalpha
External IDs	OMIM: 602408; MGI: 2444210; HomoloGene: 23324; GeneCards: NR1D1; OMA:NR1D1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,100,589 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,666,159 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; pancreatic ductal cell; ; right lung; ; ectocervix; ; tibialis anterior muscle; ; paraflocculus of cerebellum; ; Brodmann area 10; ; right hemisphere of cerebellum; ; nipple;
	Top expressed in
	neural layer of retina; ; lip; ; ankle; ; superior frontal gyrus; ; esophagus; ; aortic valve; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; triceps brachii muscle; ; ankle joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear receptor activity; core promoter sequence-specific DNA binding; protein binding; heme binding; transcription corepressor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; transcription cis-regulatory region binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	cytoplasm; cell projection; dendritic spine; nucleoplasm; dendrite; nucleus; nuclear body; RNA polymerase II transcription regulator complex;
Biological process	cell differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of transcription, DNA-templated; rhythmic process; circadian temperature homeostasis; positive regulation of bile acid biosynthetic process; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; regulation of fat cell differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of lipid metabolic process; glycogen biosynthetic process; regulation of circadian rhythm; circadian rhythm; proteasomal protein catabolic process; transcription initiation from RNA polymerase II promoter; response to leptin; negative regulation of transcription, DNA-templated; cellular response to lipopolysaccharide; regulation of type B pancreatic cell proliferation; negative regulation of toll-like receptor 4 signaling pathway; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; cholesterol homeostasis; multicellular organism development; hormone-mediated signaling pathway; response to lipid; positive regulation of transcription by RNA polymerase II; negative regulation of cold-induced thermogenesis; protein destabilization; regulation of circadian sleep/wake cycle; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of inflammatory response; negative regulation of astrocyte activation; cellular response to interleukin-1; cellular response to tumor necrosis factor; negative regulation of neuroinflammatory response; negative regulation of microglial cell activation;
	Sources:Amigo / QuickGO
Orthologs
	9572
	217166
	ENSG00000126368
	ENSMUSG00000020889
	P20393
	Q3UV55
	NM_021724
	NM_145434
	NP_068370
	NP_663409
	Wikidata
View/Edit Human	View/Edit Mouse

Rev-Erb alpha (Rev-Erbɑ), also known as nuclear receptor subfamily 1 group D member 1 (NR1D1), is one of two Rev-Erb proteins in the nuclear receptor (NR) family of intracellular transcription factors. In humans, REV-ERBɑ is encoded by the NR1D1 gene, which is highly conserved across animal species.

Rev-Erbɑ plays an important role in regulation of the core circadian clock through repression of the positive clock element Bmal1. It also regulates several physiological processes under circadian control, including metabolic and immune pathways. Rev-Erbɑ mRNA demonstrates circadian oscillation in its expression, and it is highly expressed in mammals in the brain and metabolic tissues such as skeletal muscle, adipose tissue, and liver.