Rhodopsin kinase
| G protein-coupled receptor kinase 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GRK1 | ||||||
| Alt. symbols | RHOK | ||||||
| NCBI gene | 6011 | ||||||
| HGNC | 10013 | ||||||
| OMIM | 180381 | ||||||
| RefSeq | NM_002929 | ||||||
| UniProt | Q15835 | ||||||
| Other data | |||||||
| EC number | 2.7.11.14 | ||||||
| Locus | Chr. 13 q34 | ||||||
| |||||||
Rhodopsin kinase (EC 2.7.11.14, rod opsin kinase, G-protein-coupled receptor kinase 1, GPCR kinase 1, GRK1, opsin kinase, opsin kinase (phosphorylating), rhodopsin kinase (phosphorylating), RK, STK14) is a serine/threonine-specific protein kinase involved in phototransduction. This enzyme catalyses the following chemical reaction:
- ATP + rhodopsin ADP + phospho-rhodopsin
Mutations in rhodopsin kinase are associated with a form of night blindness called Oguchi disease.