Ribonuclease III
| Ribonuclease III domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Ribonuclease III structure interacting with double stranded RNA. | |||||||||||
| Identifiers | |||||||||||
| Symbol | RNase_III | ||||||||||
| Pfam | PF00636 | ||||||||||
| InterPro | IPR000999 | ||||||||||
| PROSITE | PDOC00448 | ||||||||||
| SCOP2 | 1jfz / SCOPe / SUPFAM | ||||||||||
| |||||||||||
Ribonuclease III (RNase III or RNase C) (BRENDA 3.1.26.3) is a type of ribonuclease that recognizes dsRNA and cleaves it at specific targeted locations to transform them into mature RNAs. These enzymes are a group of endoribonucleases that are characterized by their ribonuclease domain, which is labelled the RNase III domain. They are ubiquitous compounds in the cell and play a major role in pathways such as RNA precursor synthesis, RNA Silencing, and the pnp autoregulatory mechanism.