Riluzole

Riluzole
Clinical data
Trade names	Rilutek, Tiglutik, Exservan, others
AHFS/Drugs.com	Monograph
MedlinePlus	a696013
Pregnancy; category	AU: B3;
Routes of; administration	By mouth
ATC code	N07XX02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx Only;
Pharmacokinetic data
Bioavailability	60±18%
Protein binding	97%
Metabolism	Hepatic (CYP1A2)
Elimination half-life	9–15 hours
Excretion	Urine (90%)
Identifiers
	IUPAC name 6-(trifluoromethoxy)benzothiazol-2-amine;
CAS Number	1744-22-5 ;
PubChem CID	5070;
IUPHAR/BPS	2326;
DrugBank	DB00740 ;
ChemSpider	4892 ;
UNII	7LJ087RS6F;
KEGG	D00775 ;
ChEMBL	ChEMBL744 ;
CompTox Dashboard (EPA)	DTXSID3045192 ;
ECHA InfoCard	100.124.754
Chemical and physical data
Formula	C8H5F3N2OS
Molar mass	234.20 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)Oc1ccc2nc(sc2c1)N;
	InChI InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) ; Key:FTALBRSUTCGOEG-UHFFFAOYSA-N ;
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Riluzole is a medication used to treat amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. Riluzole delays the onset of ventilator-dependence or tracheostomy in some people and may increase survival by two to three months. Riluzole is available in tablet and liquid form.