Ro60-0175

Ro60-0175
Clinical data
Other names	(S)-5,6-Difluoroindolmethylethylamine
Identifiers
	IUPAC name (S)-6-Chloro-5-fluoro-1H-indole-2-propanamine;
CAS Number	169675-09-6 ;
PubChem CID	3045227;
IUPHAR/BPS	274;
ChemSpider	2308002;
UNII	YQP8J4N96A;
ChEBI	CHEBI:142183;
CompTox Dashboard (EPA)	DTXSID801028190 ;
ECHA InfoCard	100.189.524
Chemical and physical data
Formula	C11H12ClFN2
Molar mass	226.68 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H](Cn1ccc2c1cc(c(c2)F)Cl)N;
	InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1; Key:XJJZQXUGLLXTHO-ZETCQYMHSA-N;
	(verify)

Ro60-0175, also known as (S)-5,6-difluoroindolmethylethylamine, is a serotonin receptor agonist of the isotryptamine group developed by Hoffmann–La Roche, which has applications in scientific research.

It acts as a potent and selective agonist of both the serotonin 5-HT_2B and 5-HT_2C receptor subtypes, with good selectivity over the closely related serotonin 5-HT_2A subtype, and little or no affinity at other receptors. However, Ro60-0175 also activates the serotonin 5-HT_2A receptor less potently than the serotonin 5-HT_2B and 5-HT_2C receptors.

In combination with the selective serotonin 5-HT_2C receptor antagonist SB-242084, Ro60-0175 robustly induces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. This effect is abolished by addition of the selective serotonin 5-HT_2A receptor antagonist ketanserin or volinanserin. The preceding findings suggest that Ro60-0175 may be a serotonergic psychedelic and may have hallucinogenic effects in humans at sufficiently high doses.