Rotigotine

Rotigotine
Clinical data
Trade names	Neupro, Leganto
AHFS/Drugs.com	Monograph
MedlinePlus	a607059
License data	US DailyMed: Rotigotine;
Pregnancy; category	AU: B3;
Routes of; administration	Transdermal
ATC code	N04BC09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	37% (transdermal)
Protein binding	92%
Metabolism	Liver (CYP-mediated)
Elimination half-life	5–7 hours
Excretion	Urine (71%), Feces (23%)
Identifiers
	IUPAC name (S)-6-[Propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8- tetrahydronaphthalen-1-ol;
CAS Number	99755-59-6 ;
PubChem CID	57537;
IUPHAR/BPS	941;
DrugBank	DB05271 ;
ChemSpider	51867 ;
UNII	87T4T8BO2E;
KEGG	D05768;
ChEMBL	ChEMBL1303 ;
CompTox Dashboard (EPA)	DTXSID5046772 ;
ECHA InfoCard	100.123.257
Chemical and physical data
Formula	C19H25NOS
Molar mass	315.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1cccc3c1CCC(N(CCC)CCc2sccc2)C3;
	InChI InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3 ; Key:KFQYTPMOWPVWEJ-UHFFFAOYSA-N ;
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Rotigotine, sold under the brand name Neupro among others, is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson's disease and restless legs syndrome. It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours.

Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.