Roxatidine acetate

Roxatidine acetate
Clinical data
Routes of; administration	Oral
ATC code	A02BA06 (WHO) ;
Pharmacokinetic data
Bioavailability	80–90%
Protein binding	5–7%
Metabolism	Hepatic deacetylation; Minor involvement of CYP2D6 and CYP2A6
Elimination half-life	5–7 hours
Excretion	Renal
Identifiers
	IUPAC name 2-oxo-2-(3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino)ethyl acetate;
CAS Number	78628-28-1 ; roxatidine: 78273-80-0 ;
PubChem CID	5105;
DrugBank	DB08806 ;
ChemSpider	4926 ;
UNII	ZUP3LSD0DO; roxatidine: IV9VHT3YUM ;
KEGG	D08495 ;
ChEMBL	ChEMBL46102 ;
CompTox Dashboard (EPA)	DTXSID2048325 ;
Chemical and physical data
Formula	C19H28N2O4
Molar mass	348.443 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(C)OCC(=O)NCCCOc1cccc(c1)CN2CCCCC2;
	InChI InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23) ; Key:SMTZFNFIKUPEJC-UHFFFAOYSA-N ;
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Roxatidine acetate is a specific and competitive histamine H₂ receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.

Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.

It was patented in 1979 and approved for medical use in 1986. It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece, and South Africa.

Clinical data

Routes of administration	Oral
ATC code	A02BA06 (WHO)
Pharmacokinetic data
Bioavailability	80–90%
Protein binding	5–7%
Metabolism	Hepatic deacetylation Minor involvement of CYP2D6 and CYP2A6
Elimination half-life	5–7 hours
Excretion	Renal
Identifiers
IUPAC name 2-oxo-2-(3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino)ethyl acetate
CAS Number	78628-28-1^Y roxatidine: 78273-80-0^Y
PubChem CID	5105
DrugBank	DB08806^Y
ChemSpider	4926^Y
UNII	ZUP3LSD0DO roxatidine: IV9VHT3YUM^Y
KEGG	D08495^Y
ChEMBL	ChEMBL46102^Y
CompTox Dashboard (EPA)	DTXSID2048325
Chemical and physical data
Formula	C₁₉H₂₈N₂O₄
Molar mass	348.443 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(C)OCC(=O)NCCCOc1cccc(c1)CN2CCCCC2
InChI InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23)^Y Key:SMTZFNFIKUPEJC-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)