Runs of homozygosity

Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring.

The potential of predicting or estimating individual autozygosity for a subpopulation is the proportion of the autosomal genome above a specified length, termed Froh.

A research study in UK Biobank, All of Us and Million Veteran Program found that FROH declines over time.

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