S100A5

S100A5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KAX, 2KAY, 4DIR
Identifiers
Aliases	S100A5, S100D, S100 calcium binding protein A5
External IDs	OMIM: 176991; MGI: 1338915; HomoloGene: 2224; GeneCards: S100A5; OMA:S100A5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,541,765 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,519,087 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; monocyte; ; olfactory zone of nasal mucosa; ; gastric mucosa; ; blood; ; Descending thoracic aorta; ; left uterine tube; ; skin of leg;
	Top expressed in
	olfactory epithelium; ; right ventricle; ; olfactory bulb; ; extraocular muscle; ; transitional epithelium of urinary bladder; ; lumbar subsegment of spinal cord; ; gastrula; ; temporal muscle; ; migratory enteric neural crest cell; ; submandibular gland;
	More reference expression data
	; ;
	More reference expression data
Orthologs
	6276
	20199
	ENSG00000196420
	ENSMUSG00000001023
	P33763
	P63084
	NM_002962; NM_001394232; NM_001394233; NM_001394234
	NM_011312
	NP_002953
	NP_035442
	Wikidata
View/Edit Human	View/Edit Mouse

S100 calcium-binding protein A5 (S100A5) is a protein that is encoded by the S100A5 gene in humans.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes, such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca²⁺ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn²⁺ and Cu²⁺, and Cu²⁺ strongly which impairs the binding of Ca²⁺. This protein is expressed in very restricted regions of the adult brain.