S1PR1

S1PR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3V2W, 3V2Y
Identifiers
Aliases	S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
External IDs	OMIM: 601974; MGI: 1096355; HomoloGene: 1071; GeneCards: S1PR1; OMA:S1PR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	101,243,713 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	115,508,721 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; ventricular zone; ; granulocyte; ; subcutaneous adipose tissue; ; apex of heart; ; left ventricle; ; right auricle of heart; ; caudate nucleus; ; right lobe of thyroid gland;
	Top expressed in
	right lung lobe; ; globus pallidus; ; dentate gyrus of hippocampal formation granule cell; ; atrium; ; left lung; ; superior frontal gyrus; ; inferior colliculi; ; mesenteric lymph nodes; ; cerebellar cortex; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingolipid binding; sphingosine-1-phosphate receptor activity; G protein-coupled receptor activity; signal transducer activity; G protein-coupled receptor binding; protein binding;
Cellular component	integral component of membrane; endosome; membrane; intrinsic component of plasma membrane; plasma membrane; membrane raft; external side of plasma membrane; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	actin cytoskeleton reorganization; T cell migration; G protein-coupled receptor signaling pathway; heart trabecula morphogenesis; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; sphingosine-1-phosphate receptor signaling pathway; positive regulation of cell migration; regulation of bone mineralization; transmission of nerve impulse; chemotaxis; positive regulation of positive chemotaxis; positive regulation of GTPase activity; brain development; regulation of cell adhesion; cell adhesion; angiogenesis; neuron differentiation; positive regulation of cell population proliferation; endothelial cell differentiation; negative regulation of stress fiber assembly; regulation of bone resorption; cell migration; signal transduction; lamellipodium assembly; positive regulation of transcription by RNA polymerase II; cardiac muscle tissue growth involved in heart morphogenesis; positive regulation of smooth muscle cell proliferation; blood vessel maturation; leukocyte chemotaxis; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1901
	13609
	ENSG00000170989
	ENSMUSG00000045092
	P21453
	O08530
	NM_001400; NM_001320730
	NM_007901
	NP_001307659; NP_001391
	NP_031927
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.