Serum amyloid A1

SAA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IP8, 4IP9
Identifiers
Aliases	SAA1, PIG4, SAA, SAA2, TP53I4, Serum amyloid A1
External IDs	OMIM: 104750; MGI: 98222; HomoloGene: 128033; GeneCards: SAA1; OMA:SAA1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,269,977 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,403,737 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; olfactory zone of nasal mucosa; ; lactiferous gland; ; salivary gland; ; minor salivary glands; ; right lung; ; gonad; ; subcutaneous adipose tissue; ; left coronary artery; ; right adrenal gland;
	Top expressed in
	left lobe of liver; ; left colon; ; internal carotid artery; ; morula; ; embryo; ; intestinal villus; ; ileum; ; jejunum; ; seminal vesicula; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; chemoattractant activity; G protein-coupled receptor binding;
Cellular component	endocytic vesicle lumen; extracellular region; high-density lipoprotein particle; cytoplasmic microtubule; extracellular exosome; extracellular space;
Biological process	positive regulation of cytosolic calcium ion concentration; receptor-mediated endocytosis; neutrophil chemotaxis; platelet activation; macrophage chemotaxis; acute-phase response; lymphocyte chemotaxis; innate immune response; negative regulation of inflammatory response; positive regulation of cell adhesion; regulation of protein secretion; positive chemotaxis; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6288
	20209
	ENSG00000173432; ENSG00000288411
	ENSMUSG00000057465
	P0DJI8
	P05367
	NM_199161; NM_000331; NM_001178006
	NM_011314; NM_001357491; NM_001379268; NM_001379269
	NP_000322; NP_001171477; NP_954630
	NP_035444; NP_001344420; NP_001366197; NP_001366198
	Wikidata
View/Edit Human	View/Edit Mouse

Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis.