SALL4

SALL4
Identifiers
Aliases	SALL4, DRRS, HSAL4, ZNF797, dJ1112F19.1, spalt-like transcription factor 4, spalt like transcription factor 4, IVIC
External IDs	OMIM: 607343; MGI: 2139360; HomoloGene: 10716; GeneCards: SALL4; OMA:SALL4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	51,802,521 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	168,609,863 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; gonad; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; trabecular bone; ; tibia; ; islet of Langerhans; ; buccal mucosa cell; ; body of pancreas;
	Top expressed in
	primitive streak; ; secondary oocyte; ; primary oocyte; ; tail of embryo; ; epiblast; ; zygote; ; embryo; ; blastocyst; ; morula; ; somite;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; nucleic acid binding; protein binding; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; intracellular membrane-bounded organelle; heterochromatin; nucleoplasm; protein-containing complex;
Biological process	ventricular septum development; neural tube closure; transcription, DNA-templated; signal transduction; embryonic limb morphogenesis; somatic stem cell population maintenance; tissue development; heart development; inner cell mass cell proliferation; stem cell population maintenance; negative regulation of transcription by RNA polymerase II; neural tube development; in utero embryonic development; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	57167
	99377
	ENSG00000101115
	ENSMUSG00000027547
	Q9UJQ4; Q6Y8G5
	Q8BX22
	NM_020436; NM_001318031
	NM_175303; NM_201395; NM_201396
	NP_001304960; NP_065169
	NP_780512; NP_958797; NP_958798
	Wikidata
View/Edit Human	View/Edit Mouse

Sal-like protein 4 (SALL4) is a transcription factor encoded by a member of the Spalt-like (SALL) gene family, SALL4. The SALL genes were identified based on their sequence homology to Spalt, which is a homeotic gene originally cloned in Drosophila melanogaster that is important for terminal trunk structure formation in embryogenesis and imaginal disc development in the larval stages. There are four human SALL proteins (SALL1, 2, 3, and 4) with structural homology and playing diverse roles in embryonic development, kidney function, and cancer. The SALL4 gene encodes at least three isoforms, termed A, B, and C, through alternative splicing, with the A and B forms being the most studied. SALL4 can alter gene expression changes through its interaction with many co-factors and epigenetic complexes. It is also known as a key embryonic stem cell (ESC) factor.