SART3

SART3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DO4, 5JJW, 5JJX, 5CTT, 5CTR, 5JPZ, 5CTQ
Identifiers
Aliases	SART3, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3, spliceosome associated factor 3, U4/U6 recycling protein
External IDs	OMIM: 611684; MGI: 1858230; HomoloGene: 40977; GeneCards: SART3; OMA:SART3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	108,561,400 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	113,910,571 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; tendon of biceps brachii; ; sural nerve; ; Achilles tendon; ; nipple; ; internal globus pallidus; ; cerebellar hemisphere; ; cerebellar vermis; ; epithelium of colon;
	Top expressed in
	tail of embryo; ; zygote; ; neural layer of retina; ; oocyte; ; primary oocyte; ; secondary oocyte; ; genital tubercle; ; epiblast; ; ventricular zone; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	U6atac snRNA binding; histone binding; U4 snRNA binding; protein binding; nucleic acid binding; ubiquitin-specific protease binding; U6 snRNA binding; RNA binding;
Cellular component	cytoplasm; Cajal body; nuclear speck; U4/U6 x U5 tri-snRNP complex; nucleoplasm; U4/U6 snRNP; U6atac snRNP; U4atac/U6atac snRNP; nucleus; ASAP complex;
Biological process	mRNA splicing, via spliceosome; nucleosome assembly; RNA processing; spliceosomal tri-snRNP complex assembly; homeostasis of number of cells; positive regulation of histone deubiquitination; hematopoietic stem cell proliferation; mRNA processing; spliceosomal snRNP assembly; cell morphogenesis; RNA splicing; regulation of gene expression; regulation of alternative mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	9733
	53890
	ENSG00000075856
	ENSMUSG00000018974
	Q15020
	Q9JLI8
	NM_014706
	NM_016926; NM_001356621; NM_001356623
	NP_055521
	NP_058622; NP_001343550; NP_001343552
	Wikidata
View/Edit Human	View/Edit Mouse

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.