SATB1

SATB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YSE, 2L1P, 2O49, 2O4A, 3NZL, 3TUO, 2MW8
Identifiers
Aliases	SATB1, SATB homeobox 1, DEFDA, KTZSL
External IDs	OMIM: 602075; MGI: 105084; HomoloGene: 2232; GeneCards: SATB1; OMA:SATB1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	18,445,588 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	52,140,318 bp
RNA expression pattern
	Top expressed in
	orbitofrontal cortex; ; frontal pole; ; thymus; ; Brodmann area 46; ; parietal lobe; ; postcentral gyrus; ; parotid gland; ; Brodmann area 10; ; entorhinal cortex; ; Brodmann area 23;
	Top expressed in
	thymus; ; molar; ; barrel cortex; ; zygote; ; secondary oocyte; ; Rostral migratory stream; ; substantia nigra; ; lacrimal gland; ; vastus lateralis muscle; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; chromatin binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding;
Cellular component	PML body; nuclear matrix; nucleoplasm; chromatin; nucleus; nuclear body;
Biological process	reflex; CD4-positive, alpha-beta T cell differentiation; CD8-positive, alpha-beta T cell differentiation; chromatin remodeling; activated T cell proliferation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; chromatin organization; transcription, DNA-templated; epidermis development; histone methylation; viral process; T cell activation;
	Sources:Amigo / QuickGO
Orthologs
	6304
	20230
	ENSG00000182568
	ENSMUSG00000023927
	Q01826
	Q60611
NM_001131010; NM_001195470; NM_002971; NM_001322871; NM_001322872;
	NM_001322873; NM_001322874; NM_001322875; NM_001322876
NM_001163630; NM_001163631; NM_001163632; NM_009122; NM_001357636;
	NM_001357637; NM_001357638; NM_001357640
NP_001124482; NP_001182399; NP_001309800; NP_001309801; NP_001309802;
	NP_001309803; NP_001309804; NP_001309805; NP_002962
NP_001157102; NP_001157103; NP_001157104; NP_033148; NP_001344565;
	NP_001344566; NP_001344567; NP_001344569
	Wikidata
View/Edit Human	View/Edit Mouse

SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene. It is a dimeric/tetrameric transcription factor with multiple DNA binding domains (CUT1, CUT2 and a Homeobox domain). SATB1 specifically binds to AT-rich DNA sequences with high unwinding propensity called base unpairing regions (BURs), containing matrix attachment regions (MARs).