SATB2

SATB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WI3, 1WIZ, 2CSF
Identifiers
Aliases	SATB2, GLSS, SATB homeobox 2
External IDs	OMIM: 608148; MGI: 2679336; HomoloGene: 32249; GeneCards: SATB2; OMA:SATB2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	199,471,266 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	57,017,809 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; mucosa of sigmoid colon; ; tibia; ; rectum; ; mucosa of ileum; ; mucosa of transverse colon; ; middle temporal gyrus; ; Brodmann area 46; ; superior frontal gyrus; ; postcentral gyrus;
	Top expressed in
	facial skeleton; ; Dermatocranium; ; membranous bone; ; mandible; ; maxilla; ; rib; ; body of femur; ; barrel cortex; ; left colon; ; molar;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	histone deacetylase complex; transcription regulator complex; nuclear matrix; nucleus; nucleoplasm;
Biological process	commitment of neuronal cell to specific neuron type in forebrain; embryonic skeletal system morphogenesis; cellular response to organic substance; chromatin remodeling; roof of mouth development; regulation of transcription, DNA-templated; embryonic pattern specification; regulation of transcription by RNA polymerase II; neuron migration; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; cartilage development; regulation of gene expression; osteoblast development; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	23314
	212712
	ENSG00000119042
	ENSMUSG00000038331
	Q9UPW6
	Q8VI24
	NM_001172509; NM_001172517; NM_015265
	NM_139146; NM_001358580; NM_001358581
	NP_001165980; NP_001165988; NP_056080
	NP_631885; NP_001345509; NP_001345510
	Wikidata
View/Edit Human	View/Edit Mouse

Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. SATB2 shows a restricted mode of expression and is expressed in certain cell nuclei . The SATB2 protein is mainly expressed in the epithelial cells of the colon and rectum, followed by the nuclei of neurons in the brain.