SREBP cleavage-activating protein

SCAP
Identifiers
Aliases	SCAP, entrez:22937, SREBF chaperone
External IDs	OMIM: 601510; MGI: 2135958; HomoloGene: 8160; GeneCards: SCAP; OMA:SCAP - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	47,477,126 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	110,214,018 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; mucosa of transverse colon; ; right lobe of liver; ; skin of abdomen; ; skin of leg; ; right hemisphere of cerebellum; ; right ovary; ; left ovary; ; right testis;
	Top expressed in
	retinal pigment epithelium; ; secondary oocyte; ; otic vesicle; ; primary oocyte; ; zygote; ; saccule; ; transitional epithelium of urinary bladder; ; epithelium of stomach; ; otic placode; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; cholesterol binding; unfolded protein binding; protein-containing complex binding; sterol binding;
Cellular component	endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; integral component of membrane; Golgi apparatus; membrane; intracellular membrane-bounded organelle; Golgi membrane; endoplasmic reticulum; cytoplasmic vesicle; protein-containing complex;
Biological process	response to hypoxia; ageing; cholesterol metabolic process; response to insulin; regulation of fatty acid biosynthetic process; negative regulation of cholesterol biosynthetic process; steroid metabolic process; lipid metabolism; regulation of fatty acid metabolic process; SREBP signaling pathway; regulation of cholesterol biosynthetic process; immune response; cellular lipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	22937
	235623
	ENSG00000114650
	ENSMUSG00000032485
	Q12770
	Q6GQT6
	NM_012235; NM_001320044
	NM_001001144; NM_001103162
	NP_001306973; NP_036367
	NP_001001144; NP_001096632
	Wikidata
View/Edit Human	View/Edit Mouse

Sterol regulatory element-binding protein cleavage-activating protein, also known as SREBP cleavage-activating protein or SCAP, is a protein that in humans is encoded by the SCAP gene.

SCAP contains a sterol-sensing domain (SSD) and seven WD domains. In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi apparatus. The SREBPs are then proteolytically cleaved and stimulate sterol biosynthesis.