SCARB1

SCARB1
Identifiers
Aliases	SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1, scavenger receptor class B member 1
External IDs	OMIM: 601040; MGI: 893578; HomoloGene: 21132; GeneCards: SCARB1; OMA:SCARB1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	124,882,668 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	125,418,158 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lobe of liver; ; left ovary; ; right ovary; ; putamen; ; caudate nucleus; ; subcutaneous adipose tissue; ; placenta;
	Top expressed in
	adrenal gland; ; cumulus cell; ; retinal pigment epithelium; ; Gonadal ridge; ; external carotid artery; ; internal carotid artery; ; neural layer of retina; ; lactiferous gland; ; yolk sac; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	apolipoprotein binding; protein homodimerization activity; virus receptor activity; transporter activity; high-density lipoprotein particle receptor activity; phosphatidylserine binding; apolipoprotein A-I binding; lipopolysaccharide binding; low-density lipoprotein particle binding; 1-phosphatidylinositol binding; protein binding; high-density lipoprotein particle binding; lipopolysaccharide immune receptor activity; amyloid-beta binding; scavenger receptor activity;
Cellular component	cytoplasm; integral component of membrane; endocytic vesicle membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; integral component of plasma membrane; cell surface; lysosomal membrane; caveola; extracellular exosome; microvillus membrane;
Biological process	cholesterol import; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; recognition of apoptotic cell; lipid transport; low-density lipoprotein particle clearance; blood vessel endothelial cell migration; positive regulation of cholesterol storage; phospholipid transport; cholesterol transport; wound healing; cholesterol catabolic process; receptor-mediated endocytosis; high-density lipoprotein particle remodeling; positive regulation of endothelial cell migration; androgen biosynthetic process; vitamin transmembrane transport; positive regulation of nitric-oxide synthase activity; endothelial cell proliferation; lipopolysaccharide transport; cholesterol efflux; phagocytosis, recognition; viral entry into host cell; intestinal absorption; cholesterol homeostasis; regulation of phagocytosis; adhesion of symbiont to host; viral process; detection of lipopolysaccharide; triglyceride homeostasis; reverse cholesterol transport; lipopolysaccharide-mediated signaling pathway; high-density lipoprotein particle clearance;
	Sources:Amigo / QuickGO
Orthologs
	949
	20778
	ENSG00000073060
	ENSMUSG00000037936
	Q8WTV0
	Q61009
	NM_005505; NM_001082959
	NM_001205082; NM_001205083; NM_016741
NP_001076428; NP_005496; NP_001354910; NP_001354911; NP_001354912;
	NP_001354913; NP_001354914; NP_001354915; NP_001354916; NP_001354917; NP_001354918
	NP_001192011; NP_001192012; NP_058021
	Wikidata
View/Edit Human	View/Edit Mouse

Scavenger receptor class B type 1 (SRB1) also known as SR-BI is a protein that in humans is encoded by the SCARB1 gene. SR-BI functions as a receptor for high-density lipoprotein.