SCARB2

SCARB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F7B, 4Q4B, 4Q4F, 4TVZ, 4TW0, 4TW2
Identifiers
Aliases	SCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, scavenger receptor class B member 2
External IDs	OMIM: 602257; MGI: 1196458; HomoloGene: 48353; GeneCards: SCARB2; OMA:SCARB2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	76,234,536 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,654,692 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; subthalamic nucleus; ; germinal epithelium; ; superior vestibular nucleus; ; external globus pallidus; ; Pons; ; pars reticulata; ; pars compacta; ; lactiferous duct; ; trigeminal ganglion;
	Top expressed in
	transitional epithelium of urinary bladder; ; iris; ; carotid body; ; ciliary body; ; median eminence; ; right lung; ; arcuate nucleus; ; ventral tegmental area; ; deep cerebellar nuclei; ; dorsal tegmental nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme binding; protein binding; virus receptor activity; phosphatidylserine binding; transmembrane signaling receptor activity; scavenger receptor activity; phospholipid transporter activity; cholesterol binding; phosphatidylcholine binding; protein homodimerization activity; chaperone binding; cargo receptor activity;
Cellular component	integral component of membrane; lysosome; lysosomal lumen; extracellular exosome; membrane; focal adhesion; lysosomal membrane; plasma membrane; clathrin-coated vesicle membrane; late endosome membrane; Golgi membrane; endoplasmic reticulum membrane; endosome membrane; endocytic vesicle membrane;
Biological process	viral entry into host cell; protein targeting to lysosome; viral process; positive regulation of neuron projection development; membrane organization; regulation of endosome organization; regulation of glucosylceramidase activity; regulation of lysosome organization; receptor-mediated endocytosis; aminophospholipid transport; regulation of cellular carbohydrate catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	950
	12492
	ENSG00000138760
	ENSMUSG00000029426
	Q14108
	O35114
	NM_005506; NM_001204255
	NM_007644
	NP_001191184; NP_005497
	NP_031670
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosomal integral membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene. LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly in the membrane of lysosome organelles; however, in cardiac muscle, LIMP-2 is also expressed at intercalated discs. LIMP-2 in a membrane protein in lysosomes that functions to regulate lysosomal/endosomal transport. Mutations in LIMP-2 have been shown to cause Gaucher disease, myoclonic epilepsy, and action myoclonus–renal failure syndrome. Abnormal levels of LIMP-2 have also been found in patients with hypertrophic cardiomyopathy.