SCEL (gene)

SCEL
Identifiers
Aliases	SCEL, sciellin
External IDs	OMIM: 604112; MGI: 1891228; HomoloGene: 2850; GeneCards: SCEL; OMA:SCEL - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	77,645,263 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	103,850,233 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; oral cavity; ; skin of arm; ; mucosa of pharynx; ; skin of hip; ; skin of abdomen; ; buccal mucosa cell; ; amniotic fluid; ; gums; ; human penis;
	Top expressed in
	conjunctival fornix; ; skin of external ear; ; corneal stroma; ; esophagus; ; hair follicle; ; skin of back; ; skin of abdomen; ; epithelium of lens; ; right lung; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	cytoplasm; extracellular exosome; membrane; cornified envelope; perinuclear region of cytoplasm;
Biological process	embryo development; epidermis development; keratinocyte differentiation; response to mechanical stimulus; positive regulation of canonical Wnt signaling pathway; embryo development ending in birth or egg hatching;
	Sources:Amigo / QuickGO
Orthologs
	8796
	64929
	ENSG00000136155
	ENSMUSG00000022123
	O95171
	Q9EQG3
	NM_001160706; NM_003843; NM_144777
	NM_022886
	NP_001154178; NP_003834; NP_659001
	NP_075024
	Wikidata
View/Edit Human	View/Edit Mouse

Sciellin is a protein that in humans is encoded by the SCEL gene.

The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.