Uteroglobin

SCGB1A1
Identifiers
Aliases	SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1, secretoglobin family 1A member 1
External IDs	OMIM: 192020; MGI: 98919; HomoloGene: 2518; GeneCards: SCGB1A1; OMA:SCGB1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,423,195 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	9,065,322 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right lung; ; mucosa of paranasal sinus; ; olfactory zone of nasal mucosa; ; urethra; ; nasal epithelium; ; lower lobe of lung; ; testicle; ; trachea; ; upper lobe of lung;
	Top expressed in
	right lung lobe; ; superior surface of tongue; ; left lung; ; left lung lobe; ; decidua; ; trachea; ; esophagus; ; bronchiole; ; embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	polychlorinated biphenyl binding; phospholipase A2 inhibitor activity; protein binding;
Cellular component	cytoplasm; rough endoplasmic reticulum; nuclear envelope; intracellular anatomical structure; secretory granule; extracellular region; endoplasmic reticulum; extracellular exosome; extracellular space;
Biological process	response to cytokine; negative regulation of interferon-gamma production; negative regulation of interleukin-5 production; negative regulation of catalytic activity; response to drug; negative regulation of interleukin-4 production; regulation of mRNA stability; female pregnancy; response to fibroblast growth factor; response to glucocorticoid; negative regulation of transcription by RNA polymerase II; response to ozone; response to organic substance; negative regulation of interleukin-13 production; response to lipopolysaccharide; negative regulation of T cell proliferation; regulation of inflammatory response; response to silicon dioxide; embryo implantation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7356
	22287
	ENSG00000149021
	ENSMUSG00000024653
	P11684
	Q06318
	NM_003357
	NM_011681
	NP_003348
	NP_035811
	Wikidata
View/Edit Human	View/Edit Mouse

Uteroglobin, or blastokinin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene.

SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: uteroglobin (UG, UGB), uteroglobin-like antigen (UGL), blastokinin, club-cell secretory protein (CCSP), Clara-cell 16 kD protein (17 in rat/mice), club-cell-specific 10 kD protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human club cell phospholipid-binding protein (hCCPBP), secretoglobin 1A member 1 (SCGB1A1).

This protein is specifically expressed in club cells in the lungs.