SCN1B

SCN1B
Identifiers
Aliases	SCN1B, ATFB13, BRGDA5, GEFSP1, sodium voltage-gated channel beta subunit 1, EIEE52, DEE52
External IDs	OMIM: 600235; MGI: 98247; HomoloGene: 810; GeneCards: SCN1B; OMA:SCN1B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,040,449 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,826,428 bp
RNA expression pattern
	Top expressed in
	primary visual cortex; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; right frontal lobe; ; muscle of thigh; ; skeletal muscle tissue; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; superior frontal gyrus; ; prefrontal cortex;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; extensor digitorum longus muscle; ; CA3 field; ; perirhinal cortex; ; triceps brachii muscle; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity involved in Purkinje myocyte action potential; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity; sodium channel regulator activity; sodium channel inhibitor activity; protein binding; transmembrane transporter binding;
Cellular component	integral component of membrane; membrane; sodium channel complex; extracellular region; voltage-gated sodium channel complex; node of Ranvier; intercalated disc; T-tubule; plasma membrane;
Biological process	membrane depolarization during Purkinje myocyte cell action potential; cardiac muscle contraction; regulation of sodium ion transport; sodium ion transport; regulation of atrial cardiac muscle cell membrane depolarization; membrane depolarization; regulation of ion transmembrane transport; cardiac muscle cell action potential involved in contraction; ion transport; cell adhesion; regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; response to pyrethroid; regulation of heart rate by cardiac conduction; chemical synaptic transmission; corticospinal neuron axon guidance; neuronal action potential propagation; axon guidance; cardiac conduction; regulation of ventricular cardiac muscle cell membrane repolarization; sodium ion transmembrane transport; locomotion; positive regulation of neuron projection development; membrane depolarization during cardiac muscle cell action potential;
	Sources:Amigo / QuickGO
Orthologs
	6324
	20266
	ENSG00000105711
	ENSMUSG00000019194
	Q07699
	P97952
	NM_001037; NM_199037; NM_001321605
	NM_011322
	NP_001028; NP_001308534; NP_950238
	NP_035452; NP_001389263
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.

Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM]