SCN2A

SCN2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KAV, 4JPZ
Identifiers
Aliases	SCN2A, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2, sodium voltage-gated channel alpha subunit 2, DEE11, EA9
External IDs	OMIM: 182390; MGI: 98248; HomoloGene: 75001; GeneCards: SCN2A; OMA:SCN2A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	165,392,310 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	65,597,791 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; cerebellar vermis; ; entorhinal cortex; ; cerebellar hemisphere; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; right hemisphere of cerebellum; ; endothelial cell;
	Top expressed in
	piriform cortex; ; lobe of cerebellum; ; cerebellar vermis; ; primary motor cortex; ; Amygdala; ; anterior amygdaloid area; ; dorsomedial hypothalamic nucleus; ; subiculum; ; cingulate gyrus; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium channel activity; voltage-gated ion channel activity; ion channel activity; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; membrane; intrinsic component of plasma membrane; sodium channel complex; plasma membrane; node of Ranvier; integral component of plasma membrane; intracellular anatomical structure; intercalated disc; T-tubule; axon; paranode region of axon; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	membrane depolarization during action potential; sodium ion transport; regulation of ion transmembrane transport; ion transport; transmembrane transport; myelination; neuronal action potential; sodium ion transmembrane transport; nervous system development; intrinsic apoptotic signaling pathway in response to osmotic stress; neuron apoptotic process; memory; cellular response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	6326
	110876
	ENSG00000136531
	ENSMUSG00000075318
	Q99250
	B1AWN6
	NM_001040142; NM_001040143; NM_021007; NM_001371246; NM_001371247
	NM_001099298; NM_001346679; NM_001346680
	NP_001035232; NP_001035233; NP_066287; NP_001358175; NP_001358176
	NP_001092768; NP_001333608; NP_001333609
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel protein type 2 subunit alpha, is a protein that in humans is encoded by the SCN2A gene. Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain sodium channel protein type 2 subunit alpha are sometimes called Na_v1.2 channels.