Nav1.4

SCN4A
Identifiers
Aliases	SCN4A, CMS16, HOKPP2, HYKPP, HYPP, NAC1A, Na(V)1.4, Nav1.4, SkM1, sodium voltage-gated channel alpha subunit 4
External IDs	OMIM: 603967; MGI: 98250; HomoloGene: 283; GeneCards: SCN4A; OMA:SCN4A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,972,918 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,244,114 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; glutes; ; thoracic diaphragm; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; tibialis anterior muscle;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; skeletal muscle tissue; ; medial head of gastrocnemius muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; lip; ; quadriceps femoris muscle; ; knee joint; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion channel activity; sodium channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; axon;
Biological process	regulation of ion transmembrane transport; ion transmembrane transport; muscle contraction; membrane depolarization during action potential; ion transport; neuronal action potential; transmembrane transport; sodium ion transport; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6329
	110880
	ENSG00000007314
	ENSMUSG00000001027
	P35499
	Q9ER60
	NM_000334
	NM_133199
	NP_000325
	NP_573462; NP_001390570
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel protein type 4 subunit alpha is a protein that in humans is encoded by the SCN4A gene.

The Na_v1.4 voltage-gated sodium channel is encoded by the SCN4A gene. Mutations in the gene are associated with hypokalemic periodic paralysis, hyperkalemic periodic paralysis, paramyotonia congenita, and potassium-aggravated myotonia.