SCN4B

SCN4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MZ2, 4MZ3
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256; MGI: 2687406; HomoloGene: 18384; GeneCards: SCN4B; OMA:SCN4B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,152,888 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,065,450 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; spinal ganglia; ; putamen; ; right hemisphere of cerebellum; ; Pons; ; caudate nucleus; ; lateral nuclear group of thalamus; ; primary visual cortex; ; Brodmann area 23; ; trigeminal ganglion;
	Top expressed in
	triceps brachii muscle; ; ankle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; knee joint; ; digastric muscle; ; extraocular muscle; ; medial head of gastrocnemius muscle; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium channel regulator activity; transmembrane transporter binding; sodium channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; membrane; intercalated disc; intrinsic component of plasma membrane; plasma membrane;
Biological process	cardiac muscle contraction; sodium ion transmembrane transport; sodium ion transport; regulation of ion transmembrane transport; cardiac muscle cell action potential involved in contraction; ion transport; regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; AV node cell action potential; regulation of heart rate by cardiac conduction; membrane depolarization during cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization;
	Sources:Amigo / QuickGO
Orthologs
	6330
	399548
	ENSG00000177098
	ENSMUSG00000046480
	Q8IWT1
	Q7M729
	NM_001142348; NM_001142349; NM_174934
	NM_001013390
	NP_001135820; NP_001135821; NP_777594
	NP_001013408
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels. The protein is encoded by the SCN4B gene. Mutations in the SCN4B are associated with long QT syndrome.

SCN4B might additionally function as a cell adhesion molecule.