SCO2

SCO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RLI
Identifiers
Aliases	SCO2, CEMCOX1, MYP6, SCO1L, SCO2 cytochrome c oxidase assembly protein, cytochrome c oxidase assembly protein, PD-ECGF, TP, Gliostatin, TYMP, ECGF1, TdRPase, SCO cytochrome c oxidase assembly protein 2, synthesis of cytochrome C oxidase 2, MC4DN2
External IDs	OMIM: 604272; MGI: 3818630; HomoloGene: 68444; GeneCards: SCO2; OMA:SCO2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,526,461 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,258,049 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; granulocyte; ; mucosa of transverse colon; ; monocyte; ; gingival epithelium; ; gonad; ; palpebral conjunctiva; ; periodontal fiber; ; right lobe of liver; ; epithelium of bronchus;
	Top expressed in
	yolk sac; ; blastocyst; ; embryo; ; duodenum; ; colon; ; proximal tubule; ; right kidney; ; muscle of thigh; ; jejunum; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; copper ion binding; metal ion binding; protein-disulfide reductase activity;
Cellular component	myofibril; mitochondrial matrix; mitochondrial inner membrane; mitochondrion; integral component of mitochondrial inner membrane; membrane; integral component of membrane;
Biological process	cellular copper ion homeostasis; copper ion transport; eye development; respiratory chain complex IV assembly; cell redox homeostasis; mitochondrial cytochrome c oxidase assembly;
	Sources:Amigo / QuickGO
Orthologs
	9997
	100126824
	ENSG00000284194
	ENSMUSG00000091780
	O43819
	Q8VCL2
	NM_005138; NM_001169109; NM_001169110; NM_001169111
	NM_001111288
	NP_001162580; NP_001162581; NP_001162582; NP_005129
	NP_001104758
	Wikidata
View/Edit Human	View/Edit Mouse

SCO2 cytochrome c oxidase assembly (also known as SCO2 homolog, mitochondrial and SCO cytochrome oxidase deficient homolog 2) is a protein that in humans is encoded by the SCO2 gene. The encoded protein is one of the cytochrome c oxidase (COX)(Complex IV) assembly factors. Human COX is a multimeric protein complex that requires several assembly factors. Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6.