SDHAF2

SDHAF2
Identifiers
Aliases	SDHAF2, C11orf79, PGL2, SDH5, succinate dehydrogenase complex assembly factor 2
External IDs	OMIM: 613019; MGI: 1913322; HomoloGene: 32370; GeneCards: SDHAF2; OMA:SDHAF2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,446,733 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,503,506 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; anterior pituitary; ; granulocyte; ; monocyte; ; mucosa of ileum; ; apex of heart; ; mucosa of transverse colon; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex;
	Top expressed in
	otic placode; ; saccule; ; interventricular septum; ; otic vesicle; ; sternocleidomastoid muscle; ; myocardium of ventricle; ; cardiac muscles; ; temporal muscle; ; digastric muscle; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	mitochondrial matrix; mitochondrion; nucleolus; cytosol;
Biological process	mitochondrial electron transport, succinate to ubiquinone; protein-FAD linkage; tricarboxylic acid cycle; mitochondrial respiratory chain complex II assembly; protein dephosphorylation; negative regulation of epithelial to mesenchymal transition; negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	54949
	66072
	ENSG00000167985
	ENSMUSG00000024668
	Q9NX18
	Q8C6I2
	NM_017841
	NM_025333
	NP_060311
	NP_079609
	Wikidata
View/Edit Human	View/Edit Mouse

Succinate dehydrogenase complex assembly factor 2, formerly known as SDH5 and also known as SDH assembly factor 2 or SDHAF2 is a protein that in humans is encoded by the SDHAF2 gene. This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with pheochromocytoma and paraganglioma.