SDHD

SDHD
Identifiers
Aliases	SDHD, CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS, succinate dehydrogenase complex subunit D, MC2DN3
External IDs	OMIM: 602690; MGI: 1914175; HomoloGene: 37718; GeneCards: SDHD; OMA:SDHD - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	112,120,016 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	50,515,112 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; kidney tubule; ; biceps brachii; ; mucosa of colon; ; right ventricle; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	right kidney; ; interventricular septum; ; extraocular muscle; ; myocardium of ventricle; ; intercostal muscle; ; cardiac muscles; ; digastric muscle; ; cardiac muscle tissue of left ventricle; ; thoracic diaphragm; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	electron transfer activity; succinate dehydrogenase activity; metal ion binding; succinate dehydrogenase (ubiquinone) activity; heme binding; ubiquinone binding;
Cellular component	integral component of membrane; mitochondrial inner membrane; mitochondrial envelope; mitochondrion; membrane; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);
Biological process	tricarboxylic acid cycle; mitochondrial electron transport, succinate to ubiquinone;
	Sources:Amigo / QuickGO
Orthologs
	6392
	66925
	ENSG00000204370
	ENSMUSG00000000171
	O14521
	Q9CXV1
	NM_001276503; NM_001276504; NM_001276506; NM_003002
	NM_025848
	NP_001263432; NP_001263433; NP_001263435; NP_002993
	NP_080124
	Wikidata
View/Edit Human	View/Edit Mouse

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as succinate dehydrogenase complex subunit D (SDHD), is a protein that in humans is encoded by the SDHD gene. Names previously used for SDHD were PGL and PGL1. Succinate dehydrogenase is an important enzyme in both the citric acid cycle and the electron transport chain. Hereditary PGL-PCC syndrome is caused by a parental imprint of the SDHD gene. Screening can begin by 6 years of age.