SEC31A

SEC31A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WXA
Identifiers
Aliases	SEC31A, ABP125, ABP130, HSPC334, SEC31L1, HSPC275, SEC31 homolog A, COPII coat complex component, NEDSOSB, HPBKS
External IDs	OMIM: 610257; MGI: 1916412; HomoloGene: 42056; GeneCards: SEC31A; OMA:SEC31A - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	82,901,166 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	100,564,093 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; pancreatic ductal cell; ; body of pancreas; ; tibia; ; Achilles tendon; ; stromal cell of endometrium; ; epithelium of colon; ; periodontal fiber; ; left ovary; ; right ovary;
	Top expressed in
	calvaria; ; tail of embryo; ; molar; ; genital tubercle; ; zygote; ; duodenum; ; yolk sac; ; lip; ; parotid gland; ; secondary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; calcium-dependent protein binding; structural molecule activity;
Cellular component	COPII-coated ER to Golgi transport vesicle; cytoplasmic vesicle; ER to Golgi transport vesicle membrane; intracellular membrane-bounded organelle; perinuclear region of cytoplasm; membrane; endoplasmic reticulum; cytoplasm; endoplasmic reticulum exit site; endoplasmic reticulum membrane; vesicle coat; Golgi membrane; cytosol; COPII vesicle coat;
Biological process	IRE1-mediated unfolded protein response; response to calcium ion; COPII vesicle coating; vesicle-mediated transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein transport; antigen processing and presentation of peptide antigen via MHC class I; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII-coated vesicle cargo loading; intracellular protein transport; COPII-coated vesicle budding; endoplasmic reticulum organization;
	Sources:Amigo / QuickGO
Orthologs
	22872
	69162
	ENSG00000138674
	ENSMUSG00000035325
	O94979
	Q3UPL0
NM_001077206; NM_001077207; NM_001077208; NM_001191049; NM_001300744;
	NM_001300745; NM_014933; NM_016211; NM_001318119; NM_001318120
NM_026969; NM_001359323; NM_001359332; NM_001359344; NM_001359348;
	NM_001359349; NM_001359350; NM_001400516; NM_001400517
NP_001070674; NP_001070675; NP_001070676; NP_001177978; NP_001287673;
	NP_001287674; NP_001305048; NP_001305049; NP_057295
NP_081245; NP_001346252; NP_001346261; NP_001346273; NP_001346277;
	NP_001346278; NP_001346279; NP_001387445; NP_001387446
	Wikidata
View/Edit Human	View/Edit Mouse

Protein transport protein Sec31A is a protein that in humans is encoded by the SEC31A gene.

The protein encoded by this gene is similar to the SEC31 protein from yeast. The yeast SEC31 protein is known to be a component of the COPII protein complex, which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms.

Halperin-Birk syndrome (HLBKS), a rare autosomal recessive neurodevelopmental disorder, is caused by a null mutation in the SEC31A gene.