Sec61 alpha 1

SEC61A1
Identifiers
Aliases	SEC61A1, HSEC61, SEC61, SEC61A, Sec61 alpha 1, Sec61 translocon alpha 1 subunit, HNFJ4, SEC61 translocon subunit alpha 1, ADTKD5
External IDs	OMIM: 609213; MGI: 1858417; HomoloGene: 55537; GeneCards: SEC61A1; OMA:SEC61A1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	128,071,683 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	88,495,887 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; stromal cell of endometrium; ; islet of Langerhans; ; anterior pituitary; ; right lobe of liver; ; smooth muscle tissue; ; body of stomach; ; left adrenal gland; ; upper lobe of left lung; ; left adrenal cortex;
	Top expressed in
	internal carotid artery; ; Ileal epithelium; ; external carotid artery; ; Paneth cell; ; utricle; ; ascending aorta; ; seminal vesicula; ; crypt of lieberkuhn of small intestine; ; lacrimal gland; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ribosome binding; signal sequence binding; protein transmembrane transporter activity; calcium channel activity;
Cellular component	integral component of membrane; cytosol; rough endoplasmic reticulum; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; membrane; endoplasmic reticulum membrane; Sec61;
Biological process	response to interferon-gamma; endoplasmic reticulum organization; SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; protein targeting to ER; protein transport; pronephric nephron development; cotranslational protein targeting to membrane; SRP-dependent cotranslational protein targeting to membrane, translocation; posttranslational protein targeting to membrane, translocation; calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	29927
	53421
	ENSG00000058262
	ENSMUSG00000030082
	P61619
	P61620
	NM_013336; NM_001400328; NM_001400329
	NM_016906
	NP_037468
	NP_058602
	Wikidata
View/Edit Human	View/Edit Mouse

Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans.

The protein encoded by this gene belongs to the SecY/Sec61α family. It plays a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein is found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which contains beta and gamma subunits.