SEC61B

SEC61B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WWB, 4CG6
Identifiers
Aliases	SEC61B, Sec61 translocon beta subunit, SEC61 translocon subunit beta
External IDs	OMIM: 609214; MGI: 1913462; HomoloGene: 38229; GeneCards: SEC61B; OMA:SEC61B - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	99,230,615 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	47,483,242 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; body of pancreas; ; oocyte; ; corpus epididymis; ; pylorus; ; anterior pituitary; ; trachea; ; olfactory zone of nasal mucosa; ; beta cell; ; right lobe of liver;
	Top expressed in
	parotid gland; ; seminal vesicula; ; submandibular gland; ; gastrula; ; islet of Langerhans; ; mandibular prominence; ; molar; ; maxillary prominence; ; somite; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	epidermal growth factor binding; protein binding; RNA binding; protein-transporting ATPase activity;
Cellular component	integral component of membrane; cytosol; membrane; Sec61; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum Sec complex;
Biological process	retrograde protein transport, ER to cytosol; IRE1-mediated unfolded protein response; ubiquitin-dependent ERAD pathway; protein transport; intracellular protein transport; SRP-dependent cotranslational protein targeting to membrane, translocation; posttranslational protein targeting to membrane, translocation; transport; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	10952
	66212
	ENSG00000106803
	ENSMUSG00000053317
	P60468
	Q9CQS8
	NM_006808
	NM_024171
	NP_006799
	NP_077133
	Wikidata
View/Edit Human	View/Edit Mouse

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.