SECIS element
| Selenocysteine insertion sequence 1 | |
|---|---|
Predicted secondary structure and sequence conservation of SECIS_1. Letters correspond to the IUPAC notation system for nucleotides. | |
| Identifiers | |
| Symbol | SECIS_1 |
| Rfam | RF00031 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| GO | GO:0001514 |
| SO | SO:1001274 |
| PDB structures | PDBe |
| Selenocysteine insertion sequence 2 | |
|---|---|
| Identifiers | |
| Symbol | SECIS_2 |
| Rfam | RF01988 |
| Other data | |
| Domain(s) | Bacteria (seed), Eukaryota (hits) |
| PDB structures | PDBe |
| Selenocysteine insertion sequence 3 | |
|---|---|
| Identifiers | |
| Symbol | SECIS_3 |
| Rfam | RF01989 |
| Other data | |
| Domain(s) | Bacteria (seed), Eukaryota (hits) |
| PDB structures | PDBe |
| Selenocysteine insertion sequence 5 | |
|---|---|
| Identifiers | |
| Symbol | SECIS_4 |
| Rfam | RF01990 |
| Other data | |
| Domain(s) | Bacteria |
| PDB structures | PDBe |
| Selenocysteine insertion sequence 5 | |
|---|---|
| Identifiers | |
| Symbol | SECIS_5 |
| Rfam | RF01991 |
| Other data | |
| Domain(s) | Eukaryota (only Plasmodium) |
| PDB structures | PDBe |
In biology, the SECIS element (SECIS: selenocysteine insertion sequence) is an RNA element around 60 nucleotides in length that adopts a stem-loop structure. This structural motif (pattern of nucleotides) directs the cell to translate UGA codons as selenocysteines (UGA is normally a stop codon). SECIS elements are thus a fundamental aspect of messenger RNAs encoding selenoproteins, proteins that include one or more selenocysteine residues.