SEMA5A

SEMA5A
Identifiers
Aliases	SEMA5A, SEMAF, semF, semaphorin 5A
External IDs	OMIM: 609297; MGI: 107556; HomoloGene: 2949; GeneCards: SEMA5A; OMA:SEMA5A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	9,546,075 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	32,696,487 bp
RNA expression pattern
	Top expressed in
	metanephric glomerulus; ; stromal cell of endometrium; ; periodontal fiber; ; synovial joint; ; nipple; ; olfactory bulb; ; sural nerve; ; parietal pleura; ; trigeminal ganglion; ; decidua;
	Top expressed in
	molar; ; internal carotid artery; ; lateral septal nucleus; ; vas deferens; ; lateral geniculate nucleus; ; external carotid artery; ; medial geniculate nucleus; ; human fetus; ; ventricular zone; ; ventromedial nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chondroitin sulfate proteoglycan binding; heparan sulfate proteoglycan binding; syndecan binding; semaphorin receptor binding; neuropilin binding; chemorepellent activity;
Cellular component	membrane; plasma membrane; extracellular exosome; integral component of membrane; extracellular space;
Biological process	negative regulation of endothelial cell apoptotic process; negative regulation of cell adhesion; cell differentiation; positive regulation of protein kinase B signaling; positive regulation of endothelial cell proliferation; positive regulation of endothelial cell chemotaxis; cell-cell signaling; positive regulation of axon extension involved in axon guidance; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; nervous system development; positive regulation of angiogenesis; multicellular organism development; diencephalon development; cell adhesion; signal clustering; cell chemotaxis; positive chemotaxis; axonal fasciculation; positive regulation of actin filament depolymerization; negative regulation of axon extension involved in axon guidance; negative chemotaxis; neural crest cell migration; positive regulation of cell migration; semaphorin-plexin signaling pathway; positive regulation of canonical Wnt signaling pathway; axon extension; neuron projection guidance;
	Sources:Amigo / QuickGO
Orthologs
	9037
	20356
	ENSG00000112902
	ENSMUSG00000022231
	Q13591
	Q62217; Q3UPZ0
	NM_003966
	NM_009154
	NP_003957
	NP_033180
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development.

Semaphorin 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions.