SENP2

SENP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TGZ, 1TH0, 2IO0, 2IO1, 2IO2, 2IO3, 3ZO5, 5AEK
Identifiers
Aliases	SENP2, AXAM2, SMT3IP2, SUMO1/sentrin/SMT3 specific peptidase 2, SUMO specific peptidase 2
External IDs	OMIM: 608261; MGI: 1923076; HomoloGene: 11005; GeneCards: SENP2; OMA:SENP2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	185,633,551 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	21,868,019 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; sural nerve; ; left testis; ; right testis; ; gastrocnemius muscle; ; corpus callosum; ; ventricular zone; ; islet of Langerhans; ; prefrontal cortex;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; granulocyte; ; fetal liver hematopoietic progenitor cell; ; neural layer of retina; ; epiblast; ; olfactory tubercle; ; visual cortex; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; endopeptidase activity; peptidase activity; protein binding; hydrolase activity; SUMO-specific endopeptidase activity; protein domain specific binding;
Cellular component	cytoplasm; nuclear membrane; membrane; nuclear pore; nucleoplasm; nucleus; cytosol; nuclear body; PML body; cytoplasmic vesicle;
Biological process	mRNA transport; Wnt signaling pathway; protein sumoylation; proteolysis; negative regulation of protein ubiquitination; regulation of Wnt signaling pathway; protein destabilization; protein transport; positive regulation of protein ubiquitination; positive regulation of protein phosphorylation; heart development; dorsal/ventral axis specification; protein desumoylation; negative regulation of protein binding; regulation of DNA endoreduplication; negative regulation of chromatin binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; fat cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of protein metabolic process; trophoblast giant cell differentiation; labyrinthine layer development; spongiotrophoblast layer development; negative regulation of signal transduction by p53 class mediator; regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	59343
	75826
	ENSG00000163904
	ENSMUSG00000022855
	Q9HC62
	Q91ZX6
	NM_021627
	NM_029457; NM_001357424
	NP_067640
	NP_083733; NP_001344353
	Wikidata
View/Edit Human	View/Edit Mouse

Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.