SENP3

SENP3
Identifiers
Aliases	SENP3, SMT3IP1, SSP3, Ulp1, SUMO1/sentrin/SMT3 specific peptidase 3, SUMO specific peptidase 3
External IDs	OMIM: 612844; MGI: 2158736; HomoloGene: 9236; GeneCards: SENP3; OMA:SENP3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,571,969 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,572,910 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; mucosa of transverse colon; ; anterior cingulate cortex; ; ganglionic eminence; ; anterior pituitary; ; ventricular zone; ; muscle layer of sigmoid colon; ; right lung; ; right testis;
	Top expressed in
	neural layer of retina; ; epiblast; ; spermatocyte; ; ciliary body; ; cumulus cell; ; maxillary prominence; ; mandibular prominence; ; ventricular zone; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; endopeptidase activity; protein binding; hydrolase activity;
Cellular component	cytoplasm; nucleolus; nucleus; nucleoplasm; MLL1 complex;
Biological process	proteolysis; rRNA processing; protein desumoylation;
	Sources:Amigo / QuickGO
Orthologs
	26168
	80886
	ENSG00000161956
	ENSMUSG00000005204
	Q9H4L4
	Q9EP97
	NM_015670
	NM_001163571; NM_030702
	NP_056485
	NP_001157043; NP_109627
	Wikidata
View/Edit Human	View/Edit Mouse

SUMO1/sentrin/SMT3 specific peptidase 3, also known as SENP3, is a protein which in humans is encoded by the SENP3 gene.

SENP3 together with SENP5, belongs to the Ulp1 branch in yeast and localize to nucleolus through B23/NPM1. SENP3 is associated and regulated by B23/nucleophosmin/NPM1 and involved in the regulation of ribosome biogenesis. SENP3 may be regulated by Arf-Mdm2-p53 pathway.